mTOR Nutrient Sensing

Gene co-expression module in Dendritic cells

View this module in SCUBA

Why this annotation

This module has moderate coherence and is enriched in cDC1 and mDC subsets. The hub genes include ST3GAL1 (sialylation/glycosylation), GPX4 (glutathione peroxidase, ferroptosis defense), BMP2K (BMP2-inducible kinase, endosomal trafficking/clathrin), RRAGC (Ragulator-Rag GTPase, mTORC1 nutrient sensing), ATP6V0A2 (vacuolar ATPase, endosomal acidification), OGA (O-GlcNAcase, O-GlcNAc cycling), ABCC4 (multidrug transporter), SPPL2A (intramembrane protease involved in MHC-II processing), SAMSN1 (immune cell signaling adaptor), KRAS (RAS signaling), SMAD7 (TGF-beta inhibitory SMAD), and APC (Wnt pathway). Several genes point to endosomal/lysosomal function and mTOR nutrient sensing (RRAGC, ATP6V0A2, BMP2K, SPPL2A), with additional metabolic and stress-response components (GPX4, OGA). The module is moderately coherent and likely combines mTOR/endosomal nutrient sensing with broader metabolic regulation in mDCs. The neighbor context (M152 is MHC-II antigen presentation, M151 has RAB11A/RAB11FIP1 vesicular recycling) supports an endosomal/trafficking theme. SPPL2A is specifically known to process CD74/invariant chain fragments in MHC-II pathway. Overall, the dominant program appears to be mTOR/endosomal nutrient sensing and metabolic regulation in myeloid DCs.

Genes

Most correlated modules

• Death Receptor Signaling · correlation 0.95
• Immature DC Metabolism · correlation 0.95
• Tolerogenic mDC · correlation 0.94
• mDC Inflammatory Activation · correlation 0.94
• DC Maturation Migration · correlation 0.92
• Non-canonical NF-κB · correlation 0.90
• MHC-I Antigen Presentation · correlation 0.90
• Chromatin Remodeling · correlation 0.88

Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.