mRNA Processing & Translation
Gene co-expression module in Dendritic cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 20 genes have a known function matching the annotation |
Why this annotation
This moderate-coherence, uniformly expressed module contains broadly expressed genes involved in general cellular housekeeping: EEF2 (elongation factor 2, translation), PABPC1 (poly-A binding protein, mRNA stability/translation), EIF3G (translation initiation factor), CSDE1 (RNA-binding protein, mRNA regulation), TRIP12 (E3 ubiquitin ligase), ATF6 (ER stress/UPR transcription factor), TENT4B (mRNA polyadenylation), BZW1 (translation regulation), ALKBH7 (RNA demethylase), CLINT1 (clathrin interactor, vesicle trafficking), PREX1 (Rac GEF), WNK1 (kinase), PAFAH1B1 (LIS1, dynein regulation). The uniform expression across all subsets, moderate coherence, and mix of translation, RNA processing, and general signaling genes indicate a housekeeping/post-transcriptional regulation module rather than a DC-specific program. ATF6 adds a mild ER stress flavor but is not dominant.
Genes
Most correlated modules
- Chromatin Remodeling · correlation 0.77
- Lysosomal Antigen Processing · correlation 0.72
- IFNγ-primed Phagocytosis · correlation 0.70
- Endosomal DC Trafficking · correlation 0.62
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.