Endosomal DC Trafficking
Gene co-expression module in Dendritic cells
| Category | Lysosomal & pahgocytosis |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 7 of 19 genes have a known function matching the annotation |
Why this annotation
This module has moderate coherence and many weak-membership genes. Hub genes include EHBP1L1 (endosomal/vesicular trafficking), FGD2 (a Rho GEF expressed in DCs, involved in endosomal trafficking and phagocytosis), GANAB (glucosidase II, ER glycoprotein processing), GAS6 (TAM receptor ligand, efferocytosis), RELT (TNF receptor family), JAK3 (cytokine signaling), DAXX (transcriptional repressor/stress), HUWE1 (E3 ubiquitin ligase). FGD2 is notably DC-enriched and involved in endosomal/phagosomal function. EHBP1L1 links endosomes to actin. The combination of FGD2, EHBP1L1, GANAB, and GAS6 suggests endosomal/phagocytic trafficking. The module increases with inflammation (delta_inflammation positive) and decreases with treatment. The weak coherence and many weak members make this uncertain, but the dominant theme is endosomal/phagocytic function in DCs.
Genes
Most correlated modules
- Actomyosin Cytoskeletal · correlation 0.76
- Chromatin Remodeling · correlation 0.75
- Alternative Splicing · correlation 0.72
- IFNγ-primed Phagocytosis · correlation 0.64
- mRNA Processing & Translation · correlation 0.62
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.