IFNγ-primed Phagocytosis
Gene co-expression module in Dendritic cells
| Category | Lysosomal & pahgocytosis |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 3 of 7 genes have a known function matching the annotation |
Why this annotation
This small, moderate-coherence module has CTSH (cathepsin H, lysosomal cysteine protease for antigen processing) and CFP (properdin, complement factor P, innate immune opsonization) as top hubs, with IFNGR1 (IFN-gamma receptor), NCOA3 (nuclear receptor coactivator/transcriptional coactivator), ABI1 (Abl interactor, actin dynamics), FAM107B, and UBE2E2 (ubiquitin-conjugating enzyme). The combination of a lysosomal protease (CTSH), complement component (CFP), and IFN-gamma receptor suggests a module related to innate immune sensing and phagocytic/proteolytic processing. The weak membership of IFNGR1 and ABI1 reduces confidence. Given its neighborhood context (near M87 lysosomal processing and M125 CD1 presentation), this likely represents a complementary innate immune/phagocytic activation program in mDCs, possibly IFN-gamma-primed antigen processing.
Genes
Most correlated modules
- CD1 Lipid Presentation · correlation 0.80
- Lysosomal Antigen Processing · correlation 0.78
- mRNA Processing & Translation · correlation 0.70
- NF-κB DC Activation · correlation 0.65
- Endosomal DC Trafficking · correlation 0.64
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.