INSL5 ENaC/ALK subtype
Gene co-expression module in Enteroendocrine cells
| Category | l cell program |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 14 of 18 genes have a known function matching the annotation |
Why this annotation
Nearly every hub gene is sharply localized to INSL5-expressing colonic L cells, including ALK (108x), the ENaC subunits SCNN1G/SCNN1B, LYPD6B, ATOH8 and VGF. The colonocyte-typical genes are localized rather than spread, so they reflect a genuine distal-colon INSL5-cell state, not contamination.
Genes
Most correlated modules
- Colonic INSL5+ L-cell · correlation 0.60
- INSL5/N-cell epithelial state · correlation 0.54
- Surface hypoxic state · correlation 0.45
- GLP-1/PYY hormone program · correlation 0.37
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.