Surface hypoxic state
Gene co-expression module in Enteroendocrine cells
| Category | l cell program |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 12 of 22 genes have a known function matching the annotation |
Why this annotation
Hub genes (LDHA, P4HA1, F3, HR, BNIP5, EMP1, SCNN1A, CKB) peak 4-8x in INSL5 cells and combine hypoxia/glycolytic genes with colonic surface epithelial genes. Its strong correlation with the BMP signaling response (0.88) supports a luminal-surface, BMP-high state of colonic INSL5 L cells. The colonocyte- and goblet-typical genes are localized to INSL5 cells, which argues against contamination.
Genes
Most correlated modules
- BMP/SMAD target genes · correlation 0.87
- Secretin/epithelial co-program · correlation 0.82
- GATA2/SMAD6 regulators · correlation 0.73
- CALCR/CDHR3 EC program · correlation 0.72
- NPW terminal maturation · correlation 0.72
- Villus EC subpopulation · correlation 0.61
- INSL5/N-cell epithelial state · correlation 0.47
- INSL5 ENaC/ALK subtype · correlation 0.45
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.