Colonic INSL5+ L-cell
Gene co-expression module in Enteroendocrine cells
| Category | l cell program |
|---|---|
| Genes | 0 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 11 of 14 genes have a known function matching the annotation |
Why this annotation
Localized to L and INSL5 cells and anchored by INSL5 and OR51E2, established markers of distal-colon L cells, with COL2A1, NEFM, PDIA5, NETO2, SCGB2A1 and TNFAIP8L3 completing the distal L-cell signature. Genes typical of other cell types are localized to these subsets, so they are genuine expression.
Genes
Most correlated modules
- L-cell VSTM2A program · correlation 0.90
- L-cell identity program · correlation 0.83
- ELR+ chemokine secretion · correlation 0.75
- GLP-1/PYY hormone program · correlation 0.73
- L-cell Accessory Program · correlation 0.66
- Colonic L-cell identity · correlation 0.65
- SCFA/neuropod sensing · correlation 0.65
- L-cell receptor/adhesion program · correlation 0.64
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.