ER Stress UPR
Gene co-expression module in Innate lymphoid cells
| Category | Stress |
|---|---|
| Genes | 7 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 4 of 7 genes have a known function matching the annotation |
Why this annotation
The top hub gene ERN1 (IRE1α) is the master sensor of ER stress and initiates the unfolded protein response (UPR). SELENOM (selenoprotein M) is an ER-resident thioredoxin-like protein involved in redox homeostasis and ER function. HLA-DPA1 and HLA-DRA are MHC class II molecules, which require ER processing and are upregulated in antigen-presenting contexts. NEO1 (neogenin) is a cell surface receptor. IL7R (CD127) is the IL-7 receptor, important for ILC/NK survival. PRKCA (PKC-alpha) is a signaling kinase. The module is enriched in inflammation (delta_inflammation = 0.368) and shows uniform expression across subsets. The combination of ERN1 (IRE1α/UPR), SELENOM (ER redox), and HLA class II (ER-processed) strongly points to an ER stress / unfolded protein response program. The MHC II genes may reflect ER stress-induced antigen presentation upregulation or a secondary ILC3-like activation state. The module coherence is strong with ERN1 as a clear hub. This is best labeled as ER stress/UPR.
Genes
ERN1, HLA-DPA1, HLA-DRA, IL7R, NEO1, PRKCA, SELENOM
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.