IL7R — Interleukin 7 receptor

IL7R belongs to a gene co-expression module in 11 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.

IL7R's module in each cell type

Cell type	Module	Shares the module with
CD4⁺ T cells	Resting memory T cell Immune regulation	ANXA1, CD300A, CDC14A, CYB561, DHRS3, DYNLT3, MYADM, NECTIN3 +5 more	View in SCUBA
CD8⁺ T cells	Naive/Memory CD8 T cell maturation	C1orf162, CD48, CD55, EEF1B2, GPR155, MATK, MYBL1, NACA +3 more	View in SCUBA
Endothelial	Leukocyte Recruitment Signaling Inflammation	BIRC3, CELSR1, CSF2RB, HAPLN3, HSD3B7, IL34, LTF, OLFM1 +6 more	View in SCUBA
Fibroblasts	MMP-driven Fibroblast Remodeling ECM remodeling	AKR1B1, ANPEP, COL27A1, COL7A1, CTSL, INHBA, MME, MMP1 +4 more	View in SCUBA
Gamma-delta T cells	TCR Signal Regulation TCR Signaling	ADORA2A, ANO9, CAMK4, CASK, CCR5, CD84, CDC14A, CXCR6 +22 more
Hematopoietic progenitor cells	Pro-B Progenitor Lymphcyte development	ARPP21, CD79A, CD79B, CYGB, DNTT, EBF1, FRMD4A, IL2RA +4 more
Innate lymphoid cells	ER Stress UPR Stress	ERN1, HLA-DPA1, HLA-DRA, NEO1, PRKCA, SELENOM	View in SCUBA
Macrophages	Hypoxia Stress Response Stress	ACE, AMPD3, APP, ASPH, BCAT1, BEX3, BHLHE41, BNIP3 +34 more	View in SCUBA
Monocytes	SPP1+ Inflammatory Macrophage Inflammatory	DOCK4, DUSP4, FLT1, GPR137B, INHBA, MMP14, NECTIN2, SDC2 +6 more	View in SCUBA
Mucosal-associated invariant T cell	T cell Homeostasis T cell maturation	APOL6, CD40LG, CNDP2, FAM118A, FCMR, GPR171, IFIH1, ISG20 +19 more
Natural Killer cells	ILC1-like NK Subset Gut residency	CD2, IL12RB2, KLRC1, LTB, SELL, SPTSSB, TMEM123, TNFSF10 +2 more	View in SCUBA

About the gene

Synonyms	CD127, IL7RA, lnc-IL7R
Chromosome	5: 35852695-35879603
Predicted location	Intracellular, Membrane
Essential gene	No
Protein class	Cancer-related genes, CD markers, Disease related genes, Human disease related genes, Predicted intracellular proteins, Predicted membrane proteins
Molecular function	Receptor

Function

Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP)

Human Protein Atlas · Open Targets · UniProt

Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.