ERN1 — Endoplasmic reticulum to nucleus signaling 1
ERN1 belongs to a gene co-expression module in 8 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
ERN1's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Cytokine signaling Immune regulation | ABCB1, ARHGEF40, AUTS2, COLQ, DSE, GPR65, IFI44, IFNGR1 +12 more | View in SCUBA |
| Fibroblasts | Unfolded Protein Response Stress | ADM, AFF4, DDX3X, DLL1, EIF4A1, HNRNPA2B1, HNRNPH1, HNRNPU +5 more | View in SCUBA |
| Gamma-delta T cells | T Cell Development T cell maturation | ANK3, ATF7IP2, CERK, FKBP11, LRIG1, MICAL2, PAG1, PBXIP1 +4 more | |
| Hematopoietic progenitor cells | Eosinophil Differentiation Granulocyte development | CLC, DTWD2, EPX, EXD3, IL5RA, MS4A3, PRG2 | |
| Innate lymphoid cells | ER Stress UPR Stress | HLA-DPA1, HLA-DRA, IL7R, NEO1, PRKCA, SELENOM | View in SCUBA |
| Macrophages | ER Stress Response Stress | ARHGEF12, ATXN7, BTBD7, CD2AP, CLIP2, DAPK1, DST, ERO1B +14 more | View in SCUBA |
| Monocytes | NF-κB Signaling Inflammatory | BIRC3, G0S2, ICAM1, IER3, IRAK2, NFKB1, PDE4B, PNRC1 +4 more | View in SCUBA |
| Mucosal-associated invariant T cell | Mucosal MAIT Homing migration & adhesion | BLK, BRD9, CCR6, DSEL, FUT7, LGALS3, LPAR6, LST1 +5 more |
About the gene
| Synonyms | IRE1, IRE1P |
|---|---|
| Chromosome | 17: 64039080-64130819 |
| Predicted location | Intracellular, Membrane |
| Essential gene | No |
| Protein class | Enzymes, Plasma proteins, Predicted intracellular proteins, Predicted membrane proteins, Transporters |
| Molecular function | Hydrolase, Kinase, Multifunctional enzyme, Serine/threonine-protein kinase, Transferase |
| Biological process | Apoptosis, Transcription, Transcription regulation, Unfolded protein response |
Function
Serine/threonine-protein kinase and endoribonuclease that acts as a key sensor for the endoplasmic reticulum unfolded protein response (UPR). In unstressed cells, the endoplasmic reticulum luminal domain is maintained in its inactive monomeric state by binding to the endoplasmic reticulum chaperone HSPA5/BiP. Accumulation of misfolded proteins in the endoplasmic reticulum causes release of HSPA5/BiP, allowing the luminal domain to homodimerize, promoting autophosphorylation of the kinase domain and subsequent activation of the endoribonuclease activity. The endoribonuclease activity is specific for XBP1 mRNA and excises 26 nucleotides from XBP1 mRNA. The resulting spliced transcript of XBP1 encodes a transcriptional activator protein that up-regulates expression of UPR target genes. Acts as an upstream signal for ER stress-induced GORASP2-mediated unconventional (ER/Golgi-independent) trafficking of CFTR to cell membrane by modulating the expression and localization of SEC16A.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.