NF-κB Secondary Response
Gene co-expression module in Intestinal stem cells and transit amplifying cells
| Category | Inflamation |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 8 genes have a known function matching the annotation |
Why this annotation
BCL3 is an IκB-family NF-κB modulator that acts as a transcriptional coactivator; ZC3H12A (MCPIP1/Regnase-1) is an NF-κB-induced mRNA decay enzyme that dampens inflammatory transcripts; PIM3 is an NF-κB-regulated survival kinase; ODC1 (ornithine decarboxylase) is a MYC/NF-κB target for polyamine synthesis; MXD1 antagonizes MYC downstream of NF-κB; LDLR is induced by inflammatory/metabolic signals; LMNA links nuclear architecture to inflammatory signaling; WEE1 is a cell-cycle checkpoint kinase. Upregulated in CD inflammation. Neighbor to M85 (NF-κB chemokines) and M46 (IEGs), this module represents a secondary/regulatory NF-κB transcriptional program controlling survival, proliferation arrest, and mRNA stability.
Genes
Most correlated modules
- EGFR-mediated Repair · correlation 0.82
- EGFR Wound Migration · correlation 0.79
- NF-κB Chemokine Response · correlation 0.75
- Immediate Early Response · correlation 0.74
- Heat Shock Response · correlation 0.69
- STAT3 Epithelial Remodeling · correlation 0.63
- Mitochondrial Stress Adaptation · correlation 0.33
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.