EGFR Wound Migration
Gene co-expression module in Intestinal stem cells and transit amplifying cells
| Category | migration & adhesion |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 9 of 9 genes have a known function matching the annotation |
Why this annotation
EPHA2 is a receptor tyrosine kinase that drives epithelial cell migration and is upregulated in wound healing and cancer; TM4SF1 is a tetraspanin that promotes cell migration and invasion; FHL2 is a focal adhesion LIM-domain protein that transduces integrin signals for migration; ERRFI1 (MIG6) is a negative feedback regulator of EGFR/ErbB signaling induced during wound response; GPRC5A is a retinoic acid-inducible GPCR expressed in lung/colon epithelium; KRT8 and KRT18 are simple epithelial keratins marking a columnar epithelial state; PHLDA2 is a stress/hypoxia-responsive pleckstrin homology domain protein; PMEPA1 is a TGF-β/androgen-responsive transmembrane protein that modulates SMAD signaling. Upregulated in UC inflammation. The module reflects an EGFR/EphA2-driven epithelial wound-migration program.
Genes
Most correlated modules
- EGFR-mediated Repair · correlation 0.82
- NF-κB Secondary Response · correlation 0.79
- NF-κB Chemokine Response · correlation 0.75
- Heat Shock Response · correlation 0.66
- Immediate Early Response · correlation 0.50
- Regenerative Epithelial · correlation 0.49
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.