EGFR-mediated Repair
Gene co-expression module in Intestinal stem cells and transit amplifying cells
| Category | Epithelial development |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 10 of 12 genes have a known function matching the annotation |
Why this annotation
Hub genes include three EGFR ligands (AREG, HBEGF, EREG), stress-responsive transcription factors (ATF3, KLF6, TRIB1), GDF15, and EDN1. This combination is characteristic of the epithelial wound-healing/EGFR-driven repair response. The module is strongly downregulated during inflammation and upregulated in remission, consistent with a homeostatic epithelial repair program that is suppressed during active disease and restored upon healing. RAB11FIP1 supports vesicular trafficking of EGFR ligands. EZR supports epithelial polarity during repair.
Genes
Most correlated modules
- Heat Shock Response · correlation 0.85
- NF-κB Secondary Response · correlation 0.82
- EGFR Wound Migration · correlation 0.82
- Immediate Early Response · correlation 0.68
- NF-κB Chemokine Response · correlation 0.63
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.