Antimicrobial Barrier Stress
Gene co-expression module in Intestinal stem cells and transit amplifying cells
| Category | Stress |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 9 genes have a known function matching the annotation |
Why this annotation
CLDN2 is a tight junction claudin strongly upregulated in IBD, associated with barrier dysfunction and inflammatory leaky gut. LYZ (lysozyme) and REG3A are antimicrobial peptides expressed by Paneth-like or stressed epithelial cells. IFI6 is an interferon-stimulated gene. TGFBI is TGF-β-induced, involved in epithelial remodeling. HLA-DQA1 links to the IFN-γ/MHC-II program seen in neighbors M93 and M53. PLEKHS1 and TESC are less characterized but co-regulated here. The module reflects an antimicrobial/barrier stress response in inflamed epithelium, upregulated in UC/CD and reversed in remission.
Genes
Most correlated modules
- MHC-II Antigen Presentation · correlation 0.68
- IFN-gamma Response · correlation 0.65
- Regenerative Epithelial · correlation 0.65
- Epithelial Oxidative Stress · correlation 0.58
- LGR5+ Stem Cell · correlation 0.54
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.