MHC-II Antigen Presentation
Gene co-expression module in Intestinal stem cells and transit amplifying cells
| Category | Inflamation |
|---|---|
| Genes | 0 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 13 of 13 genes have a known function matching the annotation |
Why this annotation
The module is dominated by MHC class II genes (HLA-DRA, HLA-DRB1, HLA-DPA1, HLA-DPB1, HLA-DQB1, HLA-DMA, HLA-DMB) and CD74 (invariant chain for MHC-II loading) — the complete antigen presentation machinery. PSMB9 (immunoproteasome), BST2 (tetherin, IFN-stimulated), IFI27, and UBE2L6 are IFN-γ-induced. LCN2 is an IBD-associated acute phase protein. All genes are core members. This is IFN-γ-driven MHC-II upregulation in epithelial cells, a hallmark of IBD inflammation. Neighbor to M53 (IFN-γ response), sharing the same upstream IFN-γ driver but focused on antigen presentation.
Genes
Most correlated modules
- IFN-gamma Response · correlation 0.87
- MHC-I Antigen Presentation · correlation 0.78
- Antimicrobial Barrier Stress · correlation 0.68
- Epithelial Oxidative Stress · correlation 0.60
- NF-κB Chemokine Response · correlation 0.51
- Regenerative Epithelial · correlation 0.43
- LGR5+ Stem Cell · correlation 0.39
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.