Mitochondrial Biogenesis
Gene co-expression module in Intestinal stem cells and transit amplifying cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 0 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 13 of 19 genes have a known function matching the annotation |
Why this annotation
Hub genes are dominated by mitochondrial components: ATP5F1D (ATP synthase subunit delta, Complex V), NDUFS6, NDUFB7, NDUFS8, NDUFS7, NDUFA3 (multiple NADH:ubiquinone oxidoreductase subunits, Complex I), ROMO1 (reactive oxygen species modulator 1, mitochondrial), TIMM13 (translocase of inner mitochondrial membrane), MRPL12, MRPS34, MRPS15 (mitochondrial ribosomal proteins), ETFB (electron transfer flavoprotein beta, fatty acid oxidation). POLR2L (RNA polymerase II subunit L), AURKAIP1 (Aurora kinase A interacting protein, mitochondrial ribosome), BLOC1S1 (biogenesis of lysosomal organelles), CYBA (cytochrome b-245 alpha, NADPH oxidase), GADD45GIP1 (growth arrest and DNA damage), ELOB (elongin B, transcription elongation), SMIM22 (small integral membrane protein). The module is tightly coherent (many 'core' members) and strongly enriched for Complex I NDUF subunits and mitochondrial ribosomal proteins, indicating a mitochondrial biogenesis/OxPhos program. This is a neighbor to M69 which also has OxPhos genes, confirming a mitochondrial neighborhood.
Genes
Most correlated modules
- Thymosin-S100 Cytoskeletal · correlation 0.89
- Metabolic Housekeeping · correlation 0.88
- S100 Cytoskeletal Stress · correlation 0.83
- Metabolic Housekeeping · correlation 0.82
- Mitochondrial OxPhos · correlation 0.81
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.