Mitochondrial OxPhos
Gene co-expression module in Intestinal stem cells and transit amplifying cells
| Category | Mitochondrial & OxPhos |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 4 of 11 genes have a known function matching the annotation |
Why this annotation
Hub genes UQCRC1 (ubiquinol-cytochrome c reductase core 1, Complex III), NDUFS2 (NADH:ubiquinone oxidoreductase, Complex I), SDHA (succinate dehydrogenase, Complex II) are canonical mitochondrial OxPhos components. PKM (pyruvate kinase) links glycolysis to mitochondrial metabolism. RPN1 (ribophorin I, ER translocon), TMBIM6 (transmembrane BAX inhibitor, ER stress), UBA1 (ubiquitin-activating enzyme), APEH (acylaminoacyl-peptide hydrolase) suggest co-regulation with protein processing. BSG (basigin/CD147, metabolic chaperone), SDC1 (syndecan-1), PIGR (polymeric immunoglobulin receptor) are more peripheral. The dominant signal is mitochondrial respiratory chain, with OxPhos genes as the top hub genes. Neighbor context (M3 also has NDUF subunits and mitochondrial genes) supports this as a mitochondrial/OxPhos module. The UC inflammation increase and remission decrease suggest metabolic upregulation during UC inflammation.
Genes
Most correlated modules
- Metabolic Housekeeping · correlation 0.93
- Metabolic Housekeeping · correlation 0.91
- Inflammatory Lipid Stress · correlation 0.86
- Mature Colonocyte · correlation 0.86
- ER Stress UPR · correlation 0.85
- Protein Glycosylation · correlation 0.84
- Mitochondrial Biogenesis · correlation 0.81
- Golgi Secretory Processing · correlation 0.81
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.