Metabolic Housekeeping
Gene co-expression module in Intestinal stem cells and transit amplifying cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 9 of 10 genes have a known function matching the annotation |
Why this annotation
Hub genes PPP1CA (protein phosphatase 1 catalytic subunit), ARPC4 (actin-related protein complex, cytoskeletal), CAPNS1 (calpain small subunit, cytoskeletal/proteolytic), COPE (COPI vesicle coat), ENO1 (glycolytic enzyme/moonlighting), PGAM1 (glycolytic enzyme), PSMC4 (proteasome ATPase), CTSZ (cathepsin Z, lysosomal), GNB2 (G-protein beta subunit) represent a mixed housekeeping module. The combination of glycolytic enzymes (ENO1, PGAM1), cytoskeletal regulators (ARPC4, CAPNS1), phosphatase signaling (PPP1CA), vesicle trafficking (COPE), and proteasome/lysosome components (PSMC4, CTSZ) points to general metabolic and proteostatic housekeeping. Uniform expression across subsets and moderate-to-strong membership support a broadly expressed housekeeping program. The decrease in CD inflammation and increase with CD treatment suggests these are baseline progenitor maintenance genes suppressed during active CD inflammation.
Genes
Most correlated modules
- ER Protein Trafficking · correlation 0.94
- Metabolic Housekeeping · correlation 0.94
- S100 Cytoskeletal Stress · correlation 0.91
- ER Protein Translocation · correlation 0.91
- Mitochondrial OxPhos · correlation 0.91
- Metabolic Housekeeping · correlation 0.89
- ER Stress UPR · correlation 0.89
- Mitochondrial Metabolism · correlation 0.89
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.