Metabolic Housekeeping
Gene co-expression module in Intestinal stem cells and transit amplifying cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 7 of 11 genes have a known function matching the annotation |
Why this annotation
Hub genes include HADH (hydroxyacyl-CoA dehydrogenase, fatty acid beta-oxidation), PPP2R1A (protein phosphatase 2A regulatory subunit, signaling), PIGT (GPI transamidase, GPI anchor biosynthesis), GNAS (G-protein alpha stimulatory, signaling), RAB1B (ER-to-Golgi vesicle trafficking), SDF4 (stromal cell-derived factor 4, ER calcium binding), MAZ (transcription factor), CD151 (tetraspanin, membrane organization), TECR (trans-2-enoyl-CoA reductase, fatty acid synthesis), RALY (RNA-binding protein), GPI (glucose-6-phosphate isomerase, glycolysis). This module is mixed, combining lipid metabolism (HADH, TECR), vesicle/ER trafficking (RAB1B, SDF4), signaling (PPP2R1A, GNAS), and glycolysis (GPI). The uniform expression and moderate coherence suggest a general housekeeping/metabolic maintenance program. Neighbor context (M8 also housekeeping metabolic) supports this interpretation.
Genes
Most correlated modules
- Mitochondrial OxPhos · correlation 0.93
- Metabolic Housekeeping · correlation 0.89
- ER Stress UPR · correlation 0.86
- Protein Glycosylation · correlation 0.85
- ER Stress UPR · correlation 0.83
- Mitochondrial Biogenesis · correlation 0.82
- DNA Damage Repair · correlation 0.82
- Mature Colonocyte · correlation 0.81
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.