Thymosin-S100 Cytoskeletal
Gene co-expression module in Intestinal stem cells and transit amplifying cells
| Category | Cytoskeletal |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 5 of 8 genes have a known function matching the annotation |
Why this annotation
Hub genes TMSB4X (thymosin beta-4, actin sequestration/cytoskeletal), S100A6 (calcyclin, S100 calcium-binding, stress/proliferation), S100A14 (S100 calcium-binding, epithelial marker), TMSB10 (thymosin beta-10, actin sequestration), GIPC1 (PDZ domain, endosomal trafficking), PPDPF (pancreatic progenitor cell differentiation factor), CSTB (cystatin B, cysteine protease inhibitor), CDC42EP5 (CDC42 effector protein 5, cytoskeletal). The module is dominated by thymosin beta proteins (TMSB4X, TMSB10) and S100 proteins (S100A6, S100A14), all involved in actin dynamics and cytoskeletal regulation. This is a classic actin-cytoskeletal module. The high mean expression (1.769) and 80% detection rate indicate broad expression. Significant increase in both UC and CD inflammation supports activation during inflammatory states. Neighbor M19 also has S100 proteins and RHOC, confirming a shared cytoskeletal neighborhood.
Genes
Most correlated modules
- S100 Cytoskeletal Stress · correlation 0.92
- Mitochondrial Biogenesis · correlation 0.89
- Golgi Secretory Processing · correlation 0.82
- Epithelial Stress Repair · correlation 0.81
- Mature Colonocyte · correlation 0.81
- Mitochondrial OxPhos · correlation 0.79
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.