Absorptive Colonocyte Identity
Gene co-expression module in Intestinal stem cells and transit amplifying cells
| Category | absorptive cell development |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 15 genes have a known function matching the annotation |
Why this annotation
GPA33 is a well-established marker of mature colonocytes/absorptive epithelium. CDHR5 (cadherin-related family member 5) marks brush border of absorptive enterocytes. PKP3 (plakophilin-3) is a desmosomal protein critical for epithelial junctions. AMN encodes amnionless, a cubilin co-receptor involved in nutrient absorption. NAPRT supports NAD biosynthesis in differentiated epithelium. ASL (argininosuccinate lyase) is a urea cycle enzyme expressed in colonocytes. FLNB and MAPK3 support cytoskeletal and signaling maturation. ADAM15 and PLCD3 are expressed in differentiated epithelial cells. Mild inflammation association and uniform expression support a homeostatic absorptive colonocyte identity program.
Genes
Most correlated modules
- Mature Colonocyte · correlation 0.78
- Glycolytic Barrier Stress · correlation 0.77
- Inflammatory Lipid Stress · correlation 0.75
- Inflammatory Colonocyte · correlation 0.67
- STAT3 Epithelial Remodeling · correlation 0.61
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.