STAT3 Epithelial Remodeling
Gene co-expression module in Intestinal stem cells and transit amplifying cells
| Category | Inflamation |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 10 of 12 genes have a known function matching the annotation |
Why this annotation
STAT3 is the master transcription factor of inflammatory epithelial responses in IBD; IRF1 is an interferon/inflammatory TF co-activated with STAT3. DSP (desmoplakin), PLEC (plectin), AHNAK, INF2, MICALL2, and SHROOM3 are cytoskeletal/junctional scaffold proteins whose remodeling is driven by STAT3 signaling during epithelial injury. MUC4 is a transmembrane mucin upregulated in inflammatory/regenerative epithelium. RRBP1 is an ER-associated ribosome receptor. PLXNB2 is a semaphorin receptor involved in epithelial-immune crosstalk. Upregulated in both UC and CD inflammation. The module represents STAT3-driven transcriptional reprogramming of epithelial cytoskeletal and barrier architecture during inflammation.
Genes
Most correlated modules
- NF-κB Secondary Response · correlation 0.63
- Absorptive Colonocyte Identity · correlation 0.61
- Inflammatory Colonocyte · correlation 0.59
- Splicing Regulation · correlation 0.55
- Mitochondrial Stress Adaptation · correlation 0.50
- IFN-gamma Response · correlation 0.49
- Epithelial Oxidative Stress · correlation 0.47
- NF-κB Chemokine Response · correlation 0.47
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.