Inflammatory Lipid Stress
Gene co-expression module in Intestinal stem cells and transit amplifying cells
| Category | Inflamation |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 12 genes have a known function matching the annotation |
Why this annotation
Hub MUC1 is an inflammation-associated mucin upregulated in IBD epithelium. SCD, DHCR24, and ELOVL6 are lipid/cholesterol biosynthesis enzymes, often co-regulated with ER stress and inflammatory reprogramming. GSDMD (gasdermin D) is the pyroptosis effector, strongly inflammation-linked. PLA2G2A is a secreted phospholipase with antimicrobial/inflammatory roles in the colon. TAPBP (tapasin) links to MHC-I antigen presentation upregulated in inflammation. SEC61A1 (ER translocon) connects to ER stress neighbor M67. The module is strongly upregulated in both UC and CD inflammation and reverses in remission, suggesting an inflammatory epithelial lipid-stress response.
Genes
Most correlated modules
- ER Stress UPR · correlation 0.87
- Mitochondrial OxPhos · correlation 0.86
- ER Stress UPR · correlation 0.81
- Hypoxia Response · correlation 0.81
- Metabolic Housekeeping · correlation 0.80
- Absorptive Colonocyte Identity · correlation 0.75
- Glycolytic Barrier Stress · correlation 0.75
- MHC-I Antigen Presentation · correlation 0.72
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.