Inflammatory Colonocyte
Gene co-expression module in Intestinal stem cells and transit amplifying cells
| Category | Inflamation |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 9 of 10 genes have a known function matching the annotation |
Why this annotation
MALL and PLAC8 are markers of colonocyte differentiation and innate immune activation. GCNT3 encodes a mucin-type O-glycosyltransferase expressed in colonocytes. CEACAM7 and KRT20 are mature colonocyte markers. TRIM15 and TRIM31 are E3 ubiquitin ligases involved in innate immune/NF-κB signaling. ME1 (malic enzyme) and SELENOP (selenoprotein P, antioxidant) reflect metabolic adaptation. The module is upregulated in inflammation, suggesting an inflammatory colonocyte differentiation state. Distinct from the IFN-γ modules — more focused on NF-κB-driven colonocyte remodeling.
Genes
Most correlated modules
- Epithelial Oxidative Stress · correlation 0.82
- Glycolytic Barrier Stress · correlation 0.67
- Absorptive Colonocyte Identity · correlation 0.67
- Regenerative Epithelial · correlation 0.66
- STAT3 Epithelial Remodeling · correlation 0.59
- IFN-gamma Response · correlation 0.48
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.