Glycolytic Barrier Stress
Gene co-expression module in Intestinal stem cells and transit amplifying cells
| Category | Stress |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 9 genes have a known function matching the annotation |
Why this annotation
PARM1 is a mucin-like protein associated with epithelial stress and barrier function. CCL28 is a mucosal chemokine (CCL28/MEC) secreted by epithelial cells during inflammation to recruit IgA-producing B cells and T cells. ACVRL1 (ALK1) is a TGF-β/BMP receptor involved in vascular and epithelial remodeling. HK2 (hexokinase 2) is a direct HIF1A transcriptional target mediating the glycolytic shift under hypoxia/inflammation — linking this module to neighbor M49. PYGB (glycogen phosphorylase) supports glycogenolysis under metabolic stress. SPINK5 is a serine protease inhibitor critical for epithelial barrier integrity. CREB3L1 is a UPR/ER stress transcription factor. B3GALT5 is a glycosyltransferase involved in mucin glycosylation. Strongly upregulated in UC inflammation, reverses in remission. This module captures a hypoxia-driven glycolytic/barrier stress program in inflamed epithelium.
Genes
Most correlated modules
- Epithelial Stress Repair · correlation 0.84
- Mature Colonocyte · correlation 0.78
- Absorptive Colonocyte Identity · correlation 0.77
- Inflammatory Lipid Stress · correlation 0.75
- Cytoskeletal Junction · correlation 0.75
- Hypoxia Response · correlation 0.72
- Inflammatory Colonocyte · correlation 0.67
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.