Mature Colonocyte
Gene co-expression module in Intestinal stem cells and transit amplifying cells
| Category | absorptive cell development |
|---|---|
| Genes | 0 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 8 of 13 genes have a known function matching the annotation |
Why this annotation
Hub GRN (granulin/progranulin) and CTSD (cathepsin D) are lysosomal proteins involved in lysosomal biogenesis and proteolysis. PSAP (prosaposin) is a lysosomal sphingolipid activator. VSIG2 and AOC1 are markers of mature colonocyte differentiation. LGALS3BP is a secreted glycoprotein associated with epithelial differentiation. SPINT1 (HAI-2) regulates epithelial serine proteases. MVP (major vault protein) is expressed in differentiated epithelium. The module is slightly downregulated in inflammation and partially restored by treatment in CD, consistent with loss of mature colonocyte identity during active IBD — a differentiation program suppressed by inflammation.
Genes
Most correlated modules
- Golgi Secretory Processing · correlation 0.88
- Mitochondrial OxPhos · correlation 0.86
- Metabolic Housekeeping · correlation 0.81
- Epithelial Stress Repair · correlation 0.81
- Thymosin-S100 Cytoskeletal · correlation 0.81
- Glycolytic Barrier Stress · correlation 0.78
- Absorptive Colonocyte Identity · correlation 0.78
- Cytoskeletal Junction · correlation 0.72
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.