NF-κB Chemokine Response
Gene co-expression module in Intestinal stem cells and transit amplifying cells
| Category | Inflamation |
|---|---|
| Genes | 0 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 8 of 8 genes have a known function matching the annotation |
Why this annotation
Hub genes CXCL1, CXCL2, CXCL3, CXCL8 are ELR+ CXC chemokines that recruit neutrophils and are prototypical NF-κB targets. IL32 is a pro-inflammatory cytokine, TNFAIP3 (A20) is a canonical NF-κB negative feedback regulator, CCL20 recruits CCR6+ immune cells, and BIRC3 is an NF-κB-regulated anti-apoptotic gene. Strongly upregulated in both UC and CD inflammation and reduced in remission. All 8 genes are direct NF-κB transcriptional targets, forming a coherent NF-κB-driven chemokine/inflammatory module. Neighbor M46 (IEGs) and M27 (NF-κB secondary response) support this inflammatory neighborhood.
Genes
Most correlated modules
- NF-κB Secondary Response · correlation 0.75
- EGFR Wound Migration · correlation 0.75
- EGFR-mediated Repair · correlation 0.63
- MHC-II Antigen Presentation · correlation 0.51
- IFN-gamma Response · correlation 0.49
- Epithelial Oxidative Stress · correlation 0.47
- STAT3 Epithelial Remodeling · correlation 0.47
- Immediate Early Response · correlation 0.44
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.