ER Stress UPR
Gene co-expression module in Intestinal stem cells and transit amplifying cells
| Category | Protein processing & ER |
|---|---|
| Genes | 0 |
| Annotation certainty | 5 of 5 |
| Annotation consistency | 7 of 10 genes have a known function matching the annotation |
Why this annotation
Top hub genes CALR (calreticulin), HSP90B1 (GRP94), PDIA4, and P4HB are canonical ER chaperones and protein disulfide isomerases central to the unfolded protein response (UPR) and ER protein quality control. VCP/p97 mediates ER-associated degradation (ERAD). CTSB is a lysosomal protease involved in ER stress-linked autophagy. FDFT1 links to sterol biosynthesis in the ER membrane. Mild upregulation in UC inflammation is consistent with ER stress in inflamed epithelium. Neighbor M14 contains SEC61A1 (ER translocon), reinforcing an ER-centered neighborhood.
Genes
Most correlated modules
- ER Stress UPR · correlation 0.91
- Metabolic Housekeeping · correlation 0.88
- Inflammatory Lipid Stress · correlation 0.87
- ER Protein Translocation · correlation 0.87
- Mitochondrial OxPhos · correlation 0.85
- Hypoxia Response · correlation 0.84
- Protein Glycosylation · correlation 0.84
- Metabolic Housekeeping · correlation 0.83
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.