Colonocyte Apical Cytoskeleton
Gene co-expression module in Microfold-like cells
| Category | Cytoskeletal |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 11 of 16 genes have a known function matching the annotation |
Why this annotation
CDX2 is the master transcription factor defining colonocyte identity. GPA33 (A33 antigen) is a highly specific colon epithelial surface marker. KCNE3 is a potassium channel subunit critical for colonocyte electrolyte transport. TMPRSS2 is expressed on colonocyte apical surfaces. B3GALT5 encodes a glycosyltransferase active in colon epithelium. TPM4, ACTN4, INF2, MYH14, and SHROOM3 are cytoskeletal proteins that maintain colonocyte apical architecture and brush border integrity. AKAP9 anchors signaling complexes at the apical domain. HLA-E provides immune surveillance context. The module is upregulated in UC inflammation, possibly reflecting reactive colonocyte remodeling. IGLC2 is likely a minor contaminant. Overall this is a colonocyte identity/apical cytoskeletal module.
Genes
Most correlated modules
- WNT Beta-catenin · correlation 0.97
- Oxidative Stress ROS · correlation 0.96
- mRNA Splicing Processing · correlation 0.96
- Stress Survival Response · correlation 0.94
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.