Oxidative Stress ROS
Gene co-expression module in Microfold-like cells
| Category | Stress |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 16 genes have a known function matching the annotation |
Why this annotation
DUOX2 and DUOXA2 are the strongest IBD-associated oxidative burst genes in intestinal epithelium, strongly upregulated in UC inflammation (delta_inflammation_UC sig.). NFE2L1 (NRF1) is a master oxidative stress transcription factor. MAP1LC3A and DEPP1 link to autophagy downstream of ROS. TYMP is induced by oxidative/inflammatory signals. MYO7B and CDHR5 are brush border components co-regulated in stressed enterocytes. GLS (glutaminase) supports metabolic reprogramming under oxidative stress. The module is significantly upregulated in UC inflammation and suppressed in remission, consistent with a reactive oxygen species/oxidative stress response.
Genes
Most correlated modules
- Colonocyte Apical Cytoskeleton · correlation 0.96
- Stress Survival Response · correlation 0.96
- Signaling Suppression · correlation 0.94
- Macrophage Oxidative Complement · correlation 0.93
- Complement Macrophage Activation · correlation 0.89
- NF-κB Inflammatory Response · correlation 0.89
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.