Stress Survival Response
Gene co-expression module in Microfold-like cells
| Category | Stress |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 6 of 11 genes have a known function matching the annotation |
Why this annotation
Hub genes include ARF3 (vesicle trafficking), GRN (lysosomal/progranulin), TMBIM1 (anti-apoptotic transmembrane BAX inhibitor), CDKN1A (p21, stress/senescence marker), and TNFRSF11A (RANK). GRN is a key lysosomal biogenesis and survival factor; TMBIM1 suppresses ER stress-induced apoptosis; CDKN1A indicates growth arrest. Together these suggest a stress-survival/anti-apoptotic program in macrophage-like cells, with lysosomal and vesicular trafficking components. Mild positive association with inflammation.
Genes
Most correlated modules
- Autophagy Lysosomal · correlation 0.99
- Non-canonical NF-κB · correlation 0.98
- Signaling Suppression · correlation 0.98
- Actin Cytoskeletal Regulation · correlation 0.97
- Macrophage Homeostasis · correlation 0.97
- Colonocyte Epithelial · correlation 0.96
- Vesicle Membrane Trafficking · correlation 0.96
- Oxidative Stress ROS · correlation 0.96
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.