WNT Beta-catenin
Gene co-expression module in Microfold-like cells
| Category | WNT pathway |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 6 of 13 genes have a known function matching the annotation |
Why this annotation
CTNNB1 (beta-catenin, central WNT pathway effector and transcriptional co-activator) is a top hub gene. XBP1 (UPR transcription factor also involved in WNT-related programs), TSC22D1 (TGF-beta/stress-responsive TF), YY1 (broad transcriptional regulator), SATB2 (chromatin organizer), GOLGA4 (Golgi scaffold), AHNAK, and YWHAZ (14-3-3 zeta, WNT pathway modulator) are co-expressed. CTNNB1 is the strongest pathway anchor. YWHAZ stabilizes beta-catenin. XBP1 has documented cross-talk with WNT signaling in intestinal cells. The module is a mixed transcriptional/signaling program with WNT/beta-catenin as the dominant identifiable pathway. Neighbor modules are proteostasis-focused, and CTNNB1 activity is known to be regulated by proteostatic mechanisms.
Genes
Most correlated modules
- Heat Shock Response · correlation 0.99
- ER Protein Folding · correlation 0.98
- mRNA Splicing Processing · correlation 0.98
- Macrophage Homeostasis · correlation 0.98
- Colonocyte Apical Cytoskeleton · correlation 0.97
- Oxidative Stress Response · correlation 0.97
- Growth Arrest Stress · correlation 0.97
- Metabolic Detoxification · correlation 0.96
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.