mRNA Splicing Processing
Gene co-expression module in Microfold-like cells
| Category | RNA processing & translation |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 7 of 13 genes have a known function matching the annotation |
Why this annotation
The top hub genes SFPQ, TRA2B, and CCNL1 are all involved in pre-mRNA splicing regulation. HNRNPAB is an hnRNP splicing/RNA processing factor. ZFP36 (TTP) regulates mRNA stability/decay. ZBTB7A is a transcriptional repressor. MCL1 is an anti-apoptotic BCL2 family member co-regulated in many cell states. GOLIM4 and GOLGB1 are Golgi structural proteins. IFRD1 is a transcriptional co-regulator. CCNL1 (cyclin L) directly regulates RNA Pol II-associated splicing. The module shows no significant disease association, suggesting a constitutive housekeeping RNA processing program. The Golgi components may reflect co-regulation of secretory pathway maintenance.
Genes
Most correlated modules
- WNT Beta-catenin · correlation 0.98
- Heat Shock Response · correlation 0.96
- Colonocyte Apical Cytoskeleton · correlation 0.96
- OxPhos & Mitochondrial · correlation 0.95
- Colonocyte Differentiation · correlation 0.95
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.