Complement Macrophage Activation
Gene co-expression module in Microfold-like cells
| Category | Antigen handling |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 6 of 8 genes have a known function matching the annotation |
Why this annotation
CFP (properdin, positive complement regulator), CLU (clusterin, complement inhibitor/chaperone), CORO1A (coronin-1A, critical for macrophage phagosome function and immune cell actin dynamics), MALT1 (paracaspase, NF-κB activation downstream of pattern recognition), RGS9 (G-protein regulator), SHF (Src-homology adapter). The module combines complement pathway components with macrophage cytoskeletal and NF-κB signaling genes. Strong positive remission_UC delta and treatment-negative response suggest this program is active in resolving inflammation. Neighbor context: less inflammatory than M75, more activation-oriented than M96.
Genes
Most correlated modules
- Interferon Chemokine Response · correlation 0.95
- Signaling Suppression · correlation 0.95
- Macrophage Oxidative Complement · correlation 0.95
- Lipid Mediator Signaling · correlation 0.93
- Oxidative Stress ROS · correlation 0.89
- IL1B Inflammatory Macrophage · correlation 0.88
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.