Focal Adhesion Migration
Gene co-expression module in Colonocytes
| Category | migration & adhesion |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 3 of 8 genes have a known function matching the annotation |
Why this annotation
PTK2 (FAK) is the canonical focal adhesion kinase driving cell migration and integrin-mediated adhesion. RASA2 is a RAS-GAP that modulates RAS activity downstream of integrin/growth factor signaling, directly linked to migration control. KATNBL1 regulates microtubule severing relevant to cell motility. The module shows significant positive delta_inflammation, consistent with inflammation-associated epithelial remodeling and migration. REST and FOXN2 are transcriptional regulators that may co-regulate migration gene programs. Small module with moderate coherence.
Genes
Most correlated modules
- Chromatin Regulatory Response · correlation 0.89
- Actin Cytoskeletal Regulation · correlation 0.87
- Epigenetic Remodeling Inflammation · correlation 0.80
- Unfolded Protein Response · correlation 0.79
- Chromatin-Coupled Splicing · correlation 0.78
- Chromatin Transcriptional Control · correlation 0.77
- Inflammasome Activation · correlation 0.75
- Inflammatory Stress Response · correlation 0.75
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.