EGFR Wound Response
Gene co-expression module in Colonocytes
| Category | Inflammation |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 12 of 35 genes have a known function matching the annotation |
Why this annotation
The module contains two EGFR ligands (AREG, HBEGF) and ERRFI1 (MIG6), a negative feedback regulator of EGFR, forming a coherent EGFR wound-response circuit. EPHA2 is an Eph receptor activated in epithelial injury. GADD45A is a canonical DNA damage/stress response gene. KLF6, MEF2D, TRIB1, and CSRNP1 are stress-responsive transcription factors. PARD6B links to epithelial polarity remodeling. B3GNT5 and RAP2B are downstream effectors. The module is significantly upregulated in inflammation (delta_inflammation = 0.547) and enriched in inf_colono, consistent with an EGFR-driven wound/repair response in inflamed colonocytes. Neighbor M124 captures the AP-1/survival arm of the same inflammatory response.
Genes
Most correlated modules
- mTOR Lysosomal Sensing · correlation 0.89
- AP-1 Stress Survival · correlation 0.80
- NF-kB Inflammatory Response · correlation 0.79
- KLF Differentiation Response · correlation 0.78
- Colonocyte Senescence · correlation 0.78
- Chromatin Regulatory Response · correlation 0.75
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.