Inflammatory Stress Response
Gene co-expression module in Colonocytes
| Category | Stress |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 11 of 22 genes have a known function matching the annotation |
Why this annotation
This module is enriched in inf_colono and upregulated in UC inflammation. Hub genes include ANXA5 (annexin V, membrane repair/apoptosis), CKLF (chemokine-like factor), CD47 ('don't eat me' signal), RAC2 (Rho GTPase, cytoskeletal/immune signaling), S100A11 (calcium-binding, inflammation), IFI16 (innate immune sensor/inflammasome), TNFRSF12A (TWEAK receptor, inflammatory signaling), FERMT1 (kindlin-1, integrin activation), ANXA3 (annexin III). The module reflects a stress/survival and inflammatory signaling program in inflamed colonocytes, with elements of apoptosis resistance, cytoskeletal remodeling, and innate immune activation. It is a neighbor of M56 and shares the inf_colono enrichment, but is more focused on cell survival and membrane/cytoskeletal stress responses.
Genes
Most correlated modules
- Wound Regenerative Response · correlation 0.84
- Inflammasome Activation · correlation 0.80
- Epithelial Innate Immunity · correlation 0.80
- Inflammatory Regenerative State · correlation 0.78
- Secretory Differentiation · correlation 0.78
- Focal Adhesion Migration · correlation 0.75
- Oxidative Inflammatory Remodeling · correlation 0.73
- MHC II Antigen Presentation · correlation 0.72
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.