Repair Cytokine Secretion
Gene co-expression module in Fibroblasts
| Category | Wound healing |
|---|---|
| Genes | 15 |
| Annotation certainty | 4 of 5 |
| Annotation consistency | 9 of 15 genes have a known function matching the annotation |
Why this annotation
Hub genes include STC1 (stanniocalcin-1, hypoxia/stress-induced secreted factor, anti-apoptotic), TNFRSF11B (OPG/osteoprotegerin, secreted RANKL decoy receptor, bone/inflammation), AREG (amphiregulin, EGFR ligand, tissue repair/wound healing), HGF (hepatocyte growth factor, tissue repair/regeneration), IL11 (IL-6 family cytokine, fibroblast-derived, fibrosis/repair), SMOX (spermine oxidase, polyamine metabolism/oxidative stress), RGS4/RGS18 (G-protein signaling regulators), IL13RA2 (IL-13 receptor, fibrosis signaling), CEMIP (hyaluronan metabolism, ECM remodeling), FST (follistatin, TGF-β/activin antagonist). This module is strongly upregulated in UC inflammation. The combination of HGF, AREG, IL11, STC1, and FST defines a fibroblast-derived tissue repair/wound healing secretome, with IL11 being a key fibrosis-driving cytokine in IBD stroma.
Genes
AREG, CEMIP, COLEC10, FST, HGF, IL11, IL13RA2, KCNF1, PAQR5, RGS18, RGS4, SLC4A7, SMOX, STC1, TNFRSF11B
Most correlated modules
- NFAT-cAMP Signaling · correlation 0.81
- Hypoxia Response · correlation 0.79
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.