HGF — Hepatocyte growth factor
HGF belongs to a gene co-expression module in 2 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
HGF's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| Fibroblasts | Repair Cytokine Secretion Wound healing | AREG, CEMIP, COLEC10, FST, IL11, IL13RA2, KCNF1, PAQR5 +6 more | View in SCUBA |
| Lymphatic endothelial | Lymphatic Valve Identity Valve formation | ALCAM, C12orf57, C17orf58, CFH, CLDN11, DEGS2, EBPL, EDNRB +13 more | View in SCUBA |
About the gene
| Synonyms | DFNB39, F-TCF, HGFB, HPTA, SF |
|---|---|
| Chromosome | 7: 81699010-81770438 |
| Predicted location | Secreted |
| Essential gene | No |
| Protein class | Cancer-related genes, Candidate cardiovascular disease genes, Disease related genes, Enzymes, Human disease related genes, Plasma proteins, Potential drug targets, Predicted secreted proteins, RAS pathway related proteins |
| Molecular function | Growth factor, Serine protease homolog |
Function
Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. Activates MAPK signaling following TMPRSS13 cleavage and activation.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.