RGS18 — Regulator of G protein signaling 18
RGS18 belongs to a gene co-expression module in 6 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
RGS18's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Th17/MAIT type-17 Th17 fate | AKT1S1, CA10, CA2, CCL20, CEBPD, GFPT2, IL22, IL4I1 +9 more | View in SCUBA |
| Fibroblasts | Repair Cytokine Secretion Wound healing | AREG, CEMIP, COLEC10, FST, HGF, IL11, IL13RA2, KCNF1 +6 more | View in SCUBA |
| Hematopoietic progenitor cells | Megakaryocyte Commitment Myeloid development | ARHGAP6, C2orf88, CLU, ITGA2B, MPIG6B, PPP1R14A, PRKAR2B, RGS10 +1 more | |
| Macrophages | Efferocytosis Anti-inflammatory Lysosomal & pahgocytosis | ABHD12, ADGRG5, AIG1, AXL, CCS, CD101, CD1D, CD300A +18 more | View in SCUBA |
| Monocytes | CCR2+ Monocyte Identity Innate immunity | CCR2, GAPT, LYST, MAP3K1, MNDA, POU2F2, SLC24A4, TMEM154 +4 more | View in SCUBA |
| Neutrophils | Endosomal Vesicle Trafficking Vesicular traficking | FKBP5, FLOT2, IQGAP1, MYO1F, RIPOR2, SMAP2, SORL1 |
About the gene
| Synonyms | RGS13 |
|---|---|
| Chromosome | 1: 192158462-192185815 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Predicted intracellular proteins |
| Molecular function | Signal transduction inhibitor |
Function
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i) alpha-1, G(i) alpha-2, G(i) alpha-3 and G(q) alpha.
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.