SMOX — Spermine oxidase
SMOX belongs to a gene co-expression module in 4 of 28 SCUBA cell types. Each module groups genes that rise and fall together in that cell type; the genes it shares a module with are its closest co-expression partners there.
SMOX's module in each cell type
| Cell type | Module | Shares the module with | |
|---|---|---|---|
| CD4⁺ T cells | Cytotoxic effector Cytotoxicity | ADGRG1, ATP8B4, CCL3, CCL4, CCL4L2, CSF2, FASLG, GNLY +10 more | View in SCUBA |
| Fibroblasts | Repair Cytokine Secretion Wound healing | AREG, CEMIP, COLEC10, FST, HGF, IL11, IL13RA2, KCNF1 +6 more | View in SCUBA |
| Macrophages | NRF2 Oxidative Stress Stress | ACOT9, AHRR, ARMC9, BASP1, CARD19, CCDC71L, CD226, CLDND1 +27 more | View in SCUBA |
| Monocytes | MET Tissue Repair Tissue homeostasis | BIN1, CXXC5, EMP2, EVA1C, JRK, MET, MPRIP, NTSR1 +3 more | View in SCUBA |
About the gene
| Synonyms | C20orf16, dJ779E11.1, FLJ20746, MGC1010, PAO, PAOh1, SMO |
|---|---|
| Chromosome | 20: 4120980-4187747 |
| Predicted location | Intracellular |
| Essential gene | No |
| Protein class | Enzymes, Metabolic proteins, Predicted intracellular proteins |
| Molecular function | Oxidoreductase |
Function
Flavoenzyme which catalyzes the oxidation of spermine to spermidine. Can also use N(1)-acetylspermine and spermidine as substrates, with different affinity depending on the isoform (isozyme) and on the experimental conditions. Plays an important role in the regulation of polyamine intracellular concentration and has the potential to act as a determinant of cellular sensitivity to the antitumor polyamine analogs. May contribute to beta-alanine production via aldehyde dehydrogenase conversion of 3-amino-propanal
Human Protein Atlas · Open Targets · UniProt
Gene annotation from the Human Protein Atlas and UniProt; see sources & licences.