NFAT-cAMP Signaling
Gene co-expression module in Fibroblasts
| Category | Inflammatory |
|---|---|
| Genes | 12 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 5 of 12 genes have a known function matching the annotation |
Why this annotation
CREM is a cAMP-responsive transcription factor involved in anti-inflammatory feedback and stress responses. RCAN1 (DSCR1) is a regulator of calcineurin/NFAT signaling induced by inflammatory cytokines and oxidative stress. ACKR3 (CXCR7) is an atypical chemokine receptor that modulates CXCL12/CXCL11 signaling in fibroblasts. CHSY1 encodes chondroitin synthase involved in ECM glycosaminoglycan production. STARD13 is a RhoGAP involved in cytoskeletal regulation. ELL2 is an RNA polymerase II elongation factor. SGIP1 is involved in clathrin-mediated endocytosis. ADGRE2 is an adhesion GPCR. SLC25A37 is a mitochondrial iron transporter. GPCPD1 is involved in glycerophosphocholine metabolism. The module is upregulated in UC and CD inflammation. CREM, RCAN1, and ACKR3 suggest a calcineurin/NFAT-cAMP regulatory program in inflamed fibroblasts, possibly representing a feedback/resolution response. The module is less coherent than neighbors, combining signaling and metabolic genes.
Genes
ACKR3, ADGRE2, ANKRD28, CHSY1, CREM, ELL2, FRMD4A, GPCPD1, RCAN1, SGIP1, SLC25A37, STARD13
Most correlated modules
- Hypoxia Response · correlation 0.89
- AP-1 Inflammatory Stress · correlation 0.83
- Repair Cytokine Secretion · correlation 0.81
- Inflammatory Fibroblast Activation · correlation 0.80
- ER Stress UPR · correlation 0.77
- Inflammatory Fibroblast Activation · correlation 0.72
- NF-κB Stress Response · correlation 0.72
- Inflammatory TF Response · correlation 0.72
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.