Endolysosomal Trafficking
Gene co-expression module in Mast cells
| Category | Degranulation |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 8 of 29 genes have a known function matching the annotation |
Why this annotation
Hub genes include LAMP1 (lysosome-associated membrane protein 1 — canonical lysosome marker), CTSB (cathepsin B — lysosomal cysteine protease), RAB5C (early endosome GTPase), SNX17 (sorting nexin, endosomal cargo retrieval), DNAJC13 (endosomal sorting/HSP40), ARF1 (COPI vesicle trafficking), SEC13 (COPII coat), SLC11A2 (DMT1 — divalent metal/iron transporter, expressed on endosomes/lysosomes), GNB2 (G-protein β subunit), WDR1 (AIP1, actin disassembly). The dominant theme is endolysosomal trafficking and lysosomal function, consistent with mast cell granule biology and antigen processing. SF3B2 and RBM6 are splicing factors that are peripheral members.
Genes
Most correlated modules
- Cytoskeletal Organization · correlation 0.86
- Phosphoinositide Cytoskeletal Signaling · correlation 0.84
- Mast Cell Activation Signaling · correlation 0.82
- Immune Activation Signaling · correlation 0.78
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.