Immune Activation Signaling
Gene co-expression module in Mast cells
| Category | Immune regulation |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 11 of 21 genes have a known function matching the annotation |
Why this annotation
Hub genes OGT, P2RY1, DOCK8, DOCK2, FMNL1, ICAM3, DEF6, MAPK14 point to immune cell activation and migration signaling. UNC13D and NBEAL2 are granule-associated genes relevant to mast cell degranulation/granule biogenesis. HELZ, CASC3 add RNA processing. TPCN1 (calcium channel) and P2RY1 (purinergic receptor) implicate calcium-dependent activation signaling. The module reflects broad mast cell immune activation with cytoskeletal and granule components, slightly elevated in UC inflammation (delta_inflammation_UC=0.404).
Genes
Most correlated modules
- Histone Methylation Regulation · correlation 0.92
- General Cellular Maintenance · correlation 0.87
- Chromatin & Ubiquitin Regulation · correlation 0.86
- Chromatin Epigenetic Regulation · correlation 0.85
- Integrin-Calcium Signaling · correlation 0.84
- UPR Secretory Stress · correlation 0.83
- Cytoskeletal Organization · correlation 0.83
- ER-Mitochondria Homeostasis · correlation 0.83
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.