Phosphoinositide Cytoskeletal Signaling
Gene co-expression module in Mast cells
| Category | Cytoskeletal |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 6 of 11 genes have a known function matching the annotation |
Why this annotation
Hub genes include INPP5D (SHIP1 — phosphoinositide 5-phosphatase, critical negative regulator of PI3K/mast cell activation), PI4KA (phosphatidylinositol 4-kinase, membrane PI metabolism), MYH9 (non-muscle myosin IIA, cytoskeletal/degranulation), WASF2 (WAVE2 — Arp2/3 activator, actin polymerization), STK24/STK26 (MST3/4 kinases, cytoskeletal/Hippo), ZBTB40 (zinc finger TF), KDM3B (H3K9 demethylase), ALMS1 (centrosomal/ciliary), GMDS (GDP-mannose 4,6-dehydratase, fucosylation). INPP5D, PI4KA, WASF2, and MYH9 form a coherent phosphoinositide signaling and actin cytoskeletal module relevant to mast cell activation and degranulation control. Strong UC inflammation trend (delta=0.869) and large remission decrease (-1.003) support an activation-linked program.
Genes
Most correlated modules
- TGF-beta Tolerance · correlation 0.88
- Chromatin Cell Cycle · correlation 0.87
- SMC Chromatin Maintenance · correlation 0.85
- Endolysosomal Trafficking · correlation 0.84
- Histone Methylation Regulation · correlation 0.81
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.