Cytoskeletal Remodeling
Gene co-expression module in Mast cells
| Category | Cytoskeletal |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 4 of 11 genes have a known function matching the annotation |
Why this annotation
Hub genes include PRR5 (mTORC2 component, regulates cytoskeletal organization), SHROOM2 (actin-binding cytoskeletal protein), FARP2 (RhoGEF activating Rac1/Cdc42, cytoskeletal remodeling), CMTM7 (chemokine-like factor involved in B-cell signaling and migration), and RNF130 (E3 ubiquitin ligase). ADSL is involved in purine biosynthesis. The cytoskeletal/migration theme (PRR5, SHROOM2, FARP2) is the most coherent sub-program. Low expression and uniform distribution. Moderate increase in UC inflammation.
Genes
Most correlated modules
- Transcriptional Metabolic Regulation · correlation 0.94
- Inflammatory IRAK3-BATF Response · correlation 0.94
- Glucocorticoid Stress Response · correlation 0.93
- Ubiquitin-Lysosomal Maintenance · correlation 0.91
- Circadian Transcription · correlation 0.91
- Calcium-GPCR Signaling · correlation 0.90
- mTOR-Cytoskeletal Regulation · correlation 0.90
- Purinergic Receptor Signaling · correlation 0.87
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.