Protein Homeostasis
Gene co-expression module in Mast cells
| Category | Housekeeping |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 12 of 24 genes have a known function matching the annotation |
Why this annotation
Hub genes include GET3 (guided entry of tail-anchored proteins to ER), SKIC8 (RNA surveillance SKI complex), PHB1 (prohibitin, mitochondrial chaperone), DARS1 and HARS1 (aminoacyl-tRNA synthetases), MARCHF5 (mitochondrial ubiquitin E3 ligase), EIF4EBP3 (translation repressor), and SEPTIN2 (cytoskeletal GTPase). The module combines protein targeting/quality control with aminoacyl-tRNA synthetase activity and general housekeeping functions. All genes show uniform expression with core membership, consistent with a broadly expressed housekeeping program. Neighbor M202 also contains aminoacyl-tRNA synthetases (EPRS1, LARS1, SARS1) and SKIC3, reinforcing a shared RNA/protein homeostasis theme across the batch.
Genes
Most correlated modules
- Aminoacyl-tRNA Synthetase · correlation 0.96
- RNA Processing & Mitochondrial · correlation 0.95
- General Housekeeping · correlation 0.94
- Lysosomal Autophagy · correlation 0.93
- MARCH Ubiquitin Ligase · correlation 0.92
- tRNA Aminoacylation · correlation 0.92
- Histone Variant Chromatin · correlation 0.91
- Mitochondrial Organization · correlation 0.90
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.