RNA Processing & Mitochondrial
Gene co-expression module in Mast cells
| Category | RNA processing & translation |
|---|---|
| Genes | 0 |
| Annotation certainty | 3 of 5 |
| Annotation consistency | 10 of 15 genes have a known function matching the annotation |
Why this annotation
Hub genes SEPTIN6 (cytoskeletal GTPase), RO60/TROVE2 (Ro60 ribonucleoprotein, RNA quality control/surveillance), MARCHF6 (ER-localized E3 ubiquitin ligase), RPP21 (RNase P subunit, tRNA processing), PRORP (mitochondrial RNase P), MRPS24 and MRPS28 (mitochondrial ribosomal proteins), MYG1 (mitochondrial RNA processing), SRRM2 (splicing). The module combines RNA processing (RNase P components, splicing) with mitochondrial ribosomal function and protein quality control. Significant increase with CD inflammation. Neighbor M202 also has mitochondrial ribosomal (MRPL38) and aminoacyl-tRNA synthetases, supporting a shared RNA/mitochondrial housekeeping neighborhood.
Genes
Most correlated modules
- Protein Homeostasis · correlation 0.95
- tRNA Aminoacylation · correlation 0.94
- MARCH Ubiquitin Ligase · correlation 0.94
- General Housekeeping · correlation 0.91
- Aminoacyl-tRNA Synthetase · correlation 0.90
- Histone Variant Chromatin · correlation 0.90
- Lysosomal Autophagy · correlation 0.88
- Splicing & Transcription · correlation 0.87
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.