NF-κB Signaling
Gene co-expression module in Mast cells
| Category | Inflammation |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 5 of 22 genes have a known function matching the annotation |
Why this annotation
Hub genes include TRAF3IP2 (ACT1/CIKS, adapter for IL-17 and CD40 signaling, NF-κB activation), DGKH (diacylglycerol kinase eta, regulates DAG second messenger in immune cells), ABHD4 (lipid hydrolase), ANK3 (ankyrin-G, cytoskeletal scaffold), KLF15 (Krüppel-like factor 15, metabolic/anti-inflammatory TF), NRCAM (cell adhesion), WNK3 (kinase). TRAF3IP2 is the strongest functional anchor pointing to NF-κB/IL-17 pathway signaling. DGKH modulates PKC/DAG signaling downstream of immune receptors. The module has low expression and detection, suggesting a subset-specific or low-activity state. Mixed regulatory/signaling program.
Genes
Most correlated modules
- Glucocorticoid Stress Response · correlation 0.94
- Calcium-GPCR Signaling · correlation 0.94
- Mast Cell Identity · correlation 0.93
- TGF-beta Tolerance · correlation 0.89
- Chromatin Cell Cycle · correlation 0.89
- Quiescence Epigenetic · correlation 0.87
- Transcriptional Regulation · correlation 0.86
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.