TGF-beta Tolerance
Gene co-expression module in Mast cells
| Category | Immune regulation |
|---|---|
| Genes | 0 |
| Annotation certainty | 2 of 5 |
| Annotation consistency | 7 of 24 genes have a known function matching the annotation |
Why this annotation
Hub genes include TGFBR2 (TGF-beta receptor II, key immunosuppressive/regulatory signaling), CBLB (E3 ubiquitin ligase that negatively regulates T/mast cell activation and promotes immune tolerance), SIN3B (transcriptional repressor/chromatin remodeling), PIK3C3 (VPS34, PI3-kinase involved in autophagy and endosomal sorting), OGA (O-GlcNAcase, nutrient sensing), PLXNC1 (semaphorin receptor, immune cell guidance), CDK15 (cyclin-dependent kinase). TGFBR2 and CBLB together strongly suggest an immune tolerance/negative regulation program. SIN3B and ZNF genes add epigenetic regulatory flavor. Significant treatment response in CD supports a regulatory role.
Genes
Most correlated modules
- Mast Cell Identity · correlation 0.94
- PI3K Inflammatory Signaling · correlation 0.91
- NF-κB Signaling · correlation 0.89
- Chromatin Cell Cycle · correlation 0.88
- Phosphoinositide Cytoskeletal Signaling · correlation 0.88
- Epigenetic Transcriptional Control · correlation 0.87
- Quiescence Epigenetic · correlation 0.87
- Transcriptional Regulation · correlation 0.85
Module annotations were drafted by a large language model from the module's genes, then reviewed and approved by a domain expert. See sources & licences.